病毒是如何欺騙你的丨冠状病毒RNA 丨混亂博物館

★歡迎訂閱混亂博物館官方頻道：http://bit.ly/2Q9cuFd 騙與被騙，總是離不開信息的博弈。在病毒入侵的過程中，比如新冠肺炎病毒，也不外如是。而人類研發的藥物，又是如何通過「反騙」防禦回去？過程並不簡單。在這場騙術大攻防中，無論是人、病毒還是藥，想要一次、終身找準自己的「位置」，都無疑是一種癡心妄想。 参考文献： A pneumonia outbreak associated with a new coronavirus of probable bat origin. Peng Zhou, Xing-Lou Yang... ., Nature (accelerated article preview) ;29 January 2020 doi:10.1038/s41586-020-2012-7 Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor. Fang Li, Wenhui Li, Michael Farzan... ., Science Vol 309 16 September 2005,1864 ~1867. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS. Yushun Wan, Jian Shang, Rachel Graham, R. S. Baric …., JVI Manuscript Posted Online. 29 Jan 2020; doi:10.1128/JVI.00127-20 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus 2019-nCoV in vitro. Cell Research 3 January 2020 doi:10.1038/s41422-020-0282-0 Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple Mutagens. Sexton NR, Smith EC, Blanc H, Vignuzzi M, Peersen OB, Denison MR. Journal of Virology. 90 (16): 7415–7428. doi:10.1128/JVI.00080-16 Coronaviruses: an overview of their replication and pathogenesis". Coronaviruses. Methods in Molecular Biology. Fehr AR, Perlman S (2015). Methods in Molecular Biology. 1282. pp. 1–23. doi:10.1007/978-1-4939-2438-7_1 Evolution of Wuhan coronavirus (2019-nCoV) and modeling of spike protein for human transmission. Xu, X.T., Chen, P., Wang, J.F., et al. (2020) Sci China Life Sci, in press, https://doi.org/10.1007/s11427-020-1637-5. ----------------------------------------------------------------------------------------------------------- 精彩視頻實時更新，歡迎訂閱+點讚+分享，並點擊小鈴鐺提醒觀看~ 簡介：都是些你不知道的，每週更新。 ★新浪微博: http://bit.ly/2w0xkgP ★Bilibili：http://bit.ly/33b4OHL ★知乎：http://bit.ly/30S21St ★搜索添加微信公眾號：混亂博物館 #病毒 #新冠肺炎 #RNA