Erika Pearce discusses the metabolism of activated T cells

Erika Pearce and colleagues at Washington University School of Medicine in St. Louis challenge previous ideas about T cell metabolism by showing that activated T cells switch from oxidative phosphorylation to aerobic glycolysis not to promote proliferation; but instead to augment the production of the antimicrobial protein IFN-γ, which is regulated by the glycolytic enzyme GAPDH. https://source.wustl.edu/2013/06/tumors-disable-immune-cells-by-using-up-sugar/